Addressing the grand-challenges that the world is facing nowadays in connection with ‘energy’, ‘information’ and ‘health’ requires the development of unconventional methods for unprecedented visualization of matter. SMARTelectron aims at developing an innovative technological platform for designing, realizing and operating all-optical rapidly-programmable phase… Leggi tutto masks for electrons. By introducing a new paradigm where properly synthesized ultrafast electromagnetic fields will be used for engineering the phase space of a free-electron wave function, we will be able to achieve unprecedented space/time/energy/momentum shaping of electron matter waves, surpassing conventional passive monolithic schemes and revolutionizing the way materials are investigated in electron microscopy. Such unique high-speed, flexible and precise full-phase multidimensional control, will enable novel advanced imaging approaches in electron microscopy with enhanced features, such as higher image-resolution, lower electron dose, faster acquisition rate, higher signal-to-noise ratio, and three-dimensional image reconstruction, together with higher temporal resolution and high energy-momentum sensitivity. In SMART-electron, we will make such potential a reality by implementing for the first time three beyond-the-state-of-the-art imaging techniques enabled by our photonicbased electron modulators, namely: (1) Ramsey-type Holography, (2) Electron Single-Pixel Imaging, and (3) Quantum Cathodoluminescence. Such new approaches will lead to unprecedented visualization of many-body states in quantum materials, real-time electrochemical reactions, and spatio-temporal localization of biomimetic nanoparticles in cells for drug delivery. By surpassing the current paradigms in terms of electron manipulation, the project has the potential to drive electron microscopy into a new and exciting age where scientists will benefit from new tools with unprecedented performances that were unimaginable until now.

Icing affects the operational safety of much of our transport and general infrastructure. Although in the last decade there have been promising advancements in surface engineering and materials science, to achieve an effective and sustainable anti-icing technology requires that the physical processes… Leggi tutto involved in icing are better understood and applied to a rational design of anti-icing surfaces and systems. Furthermore, the arrival of hybrid or fully-electric engines, requires that new technologies also be developed for ice protection purposes suited to these new aircraft types. Already today, all new electric urban air mobility and unmanned aerial systems (UAS) developers and start-ups are experiencing difficulties in finding icing and inclement weather specialists. This is because such training is very specialized and the required skills take years to develop. SURFICE will address both aspects. 13 talented early stage researchers will be trained by an international, interdisciplinary and intersectoral consortium of experts in materials and surface science, physics and engineering. The project will address three major research objectives: (i) investigate icing physics on complex surfaces to understand and model ice formation, accretion and adhesion; (ii) achieve rational design for anti-icing materials and coatings based on a novel concept of discontinuity-enhanced icephobicity; and (iii) develop new technologies for efficient ice prevention and control. The proposed anti-icing solutions will be directly applied in aeronautics, energy systems and sensor technologies, as well as glass manufacturing and automotive industry through industrial partners. Intertwining surface science and engineering will benefit icing research, but also other innovative emerging technologies, where surface phenomena play a crucial role. Training on scientific, transferable and entrepreneurial skills will complete the CVs of the young researchers providing an innovation-oriented mind-set.

This proposal is the continuation of the BRIEFCASE ongoing EIT RM project which is developing an innovative tool dedicated to the 6-14 years old pupils/students to show the significances of the daily use of RM and their exploitation. The aim… Leggi tutto of this new phase is to extent the scope and the target audience by improving the innovative popular science tool (the virtual briefcase) using augmented reality and turning it into a 3D application.

NEUREKA will bring a paradigm shift in drug discovery for neurological diseases, a sector that suffers multiple, repeated failures exacerbating the economical and societal burden of these incurable diseases. It will do so by addressing a crucial shortcoming: the lack… Leggi tutto of in vitro systems faithfully reproducing brain pathology that enable the functional assessment of candidate compounds at multiple levels: from synapses to neuronal circuits. NEUREKA introduces an innovative, hybrid technology, whereby detailed, computational neuronal networks simulate dysfunction and drive cultured neurons to replicate in-brain disease conditions. Nanoelectrodes mediate the transmission between simulated and biological neurons. Akin to real synapses, nanoelectrodes contact cultured neurons at subcellular locations across the dendritic tree, soma and axonal branches, allowing to control and monitor neural activity with unprecedented accuracy. Biological neuronal responses registered by nanoelectrodes are fed back to simulated neurons, closing the loop and enabling control of activity states across the hybrid population. Complementing molecular deficits already present in culture models of a disease, computational models enable replication of both molecular and physiological deficits of neurodegeneration in vitro. Cultured neurons are driven towards pathological excitability states where deficits emerge, so as to optimize quantification of the impact of drugs, going well beyond standard cellular assays. A proof-of-concept will be provided for Alzheimer’s disease, using human induced pluripotent stem cell (iPSC)-derived neurons exhibiting the pathology. NEUREKA will be used to demonstrate the effect of drug candidates across synaptic, neuronal and network functions.